Abstract P1-09-21: Metabolic syndrome is prevalent in women with newly diagnosed breast cancer

Abstract

Abstract Purpose: We estimate the prevalence of metabolic syndrome (MetSyn) among women with newly diagnosed breast cancer and explore potential risk factors. Methods: From January 2012 to May 2014, women with newly diagnosed localized breast cancer were enrolled into a longitudinal survivorship study. At baseline, results of physical exam, use of concomitant medications, serum lipid profile and vitamin D were obtained from the medical record, while quality of life variables were measured via questionnaires in English. MetSyn was defined as at least 3 of 5 criteria: central obesity (BMI >30 or waist >=88 cm); triglycerides >=150 mg/dL; HDL cholesterol <50 mg/dL or cholesterol-lowering treatment; systolic >=130 or diastolic >=85 mm Hg blood pressure or treatment for hypertension; fasting glucose >=100mg/dL or diagnosis of Type 2 diabetes. Risk factors for MetSyn (age, education, serum vitamin D, self-reported energy in past month) were evaluated using multivariate logistic regression. Results: Subjects (n=154) were age 52.0 +10.1 years. Prevalence of MetSyn at baseline was 46.1(+4.0)%; for another 1.9(+1.1)% (n=3), MetSyn status was indeterminate due to lack of data on HDL and triglycerides. Among subjects with MetSyn (n=71), most had been diagnosed with hypertension (81.7%) and diabetes (61.4%). Without MetSyn (n=80), the latter conditions were much less prevalent (31.3% and 22.5%, respectively, both p<0.0001). Adjusted for race and year of accrual, the likelihood of MetSyn at baseline was higher per year of age (Odds Ratio (O.R.) 1.05, 95% CI 1.01-1.10, p=0.015), lower per increasing educational attainment (from less than high school to high school/some college, to bachelor’s, to graduate degree: O.R. 0.58, 0.36-0.93, p=0.024), and higher per increasing "time in past month with a lot of energy" (from little/no time to most of the time, to all of the time: O.R. 2.30, 1.11-4.75, p=0.025). An inverse association with serum Vit D (p=0.14) did not reach statistical significance. Conclusions: Metabolic syndrome is present in nearly half of women newly diagnosed with breast cancer and is associated with age, less education, and more energy in past month. Citation Format: Louise C Wong, Carolyn Behrendt, Robin Smith, Joanne E Mortimer. Metabolic syndrome is prevalent in women with newly diagnosed breast cancer [abstract]. In: Proceedings of the Thirty-Seventh Annual CTRC-AACR San Antonio Breast Cancer Symposium: 2014 Dec 9-13; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2015;75(9 Suppl):Abstract nr P1-09-21.