Abstract
Abstract Background: 27-hydoxycholesterol (27-HC) is a metabolite of cholesterol (Chol) and known as endogeneous selective estrogen receptor modulator (SERM). Laboratory researches showed high 27-HC could stimulate cancer cell proliferation and promote metastasis processes in hormone receptor positive breast cancer. However, there is no clinical data about the effect of 27-HC on disease recurrence in early breast cancer. Methods: A total of 539 early breast cancer patients who underwent surgery at the National Cancer Center Hospital between 2001 and 2010 with the deposition of blood samples at Tumor Bank were accrued. The blood samples were taken with overnight fasting at surgery day. Serum 27-HC was analyzed by liquid chromatography–mass spectrometry (LC-MS). 27-HC and Chol were categorized into two groups (low vs high) by median, respectively. Results : Hormone receptor was positive in 441 patients and negative in 98 while HER2 was positive in 81, negative in 325 and unknown in 133 patients. The median follow up time was 92 months (range 24 -153.7). The 27-HC (median, 115.73 ng/ml with the range of 29.36- 234.0) and Chol (median, 170.0 mg/dl with the range of 91- 290) showed weak correlation (ρ=0.24, P<0.001). While 27-HC was not significant in analysis for RFS in all cases, it showed marginal significance for RFS in the subset analysis with HER2-negative luminal breast cancer patients (HR, 0.463; 95% CI, 0.208-1.031; P = 0.059). When the patients were grouped according to 27-HC and Chol level (group27HC/Chol) in luminal subgroup, it showed a trend for increasing RFS in the order of grouplow/high , grouplow/low, grouphigh/low and grouphigh/high(Ptrend= 0.009). Conclusion : Serum 27-HC was not associated with poor RFS. High serum 27-HC could be related to good prognosis in HER2-negative luminal type of breast cancer, which may be related to the protective effect of 27-HC from disease recurrence. Further study is warranted. Citation Format: Sung Hoon S, In Hae P, So-Youn J, Seeyoun L, Sun-Young K, Han-Sung K, Eun Sook L, Keun Seok L. Protective effect of 27-hydoxycholesterol on disease recurrence in HER2-negative luminal type of early breast cancer [abstract]. In: Proceedings of the 2017 San Antonio Breast Cancer Symposium; 2017 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2018;78(4 Suppl):Abstract nr P1-07-19.
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