Abstract
Background: Chronic kidney disease (CKD) increases the risk of arrhythmias and sudden cardiac death; however, it is unclear whether this association is due to cardiac overload, cardiac injury, electrolyte abnormalities, anemia, or all of the above. We therefore investigated the relationships between several biomarkers representing these conditions with various arrhythmias among CKD. Methods: In 2016-17 (visit 5), 2187 older participants (71-94 years) in the ARIC Study underwent 2-week continuous heart rhythm monitoring (Zio XT Patch). We conducted a cross-sectional study of 1276 participants with CKD. We used modified Poisson regression to examine the associations of natriuretic peptide (NT-proBNP) representing cardiac overload, high-sensitivity cardiac troponin-T (hs-cTnT) reflecting cardiac injury, potassium and magnesium (electrolyte abnormalities), and hemoglobin (anemia) with arrhythmias detected during the 2-week period: atrial fibrillation (AF), non-sustained ventricular tachycardia (NSVT), long pause (>3 sec), Mobitz II or complete atrioventricular block (AVB), and ventricular ectopy (VE). Results: There were 9% with AF, 33% with NSVT, 4% with long pause, 2% with AVB, and 29% with VE. NT-proBNP was associated with all arrhythmias except AVB ( Table 1 ). Higher hs-cTnT was associated with AF, NSVT, and VE. Lower potassium below 4.2 mmol/L was associated with AF while lower magnesium below <2 mg/dL was associated with VE. Hemoglobin showed no associations with arrhythmias. Conclusions: Of the plausible mechanisms contributing to arrhythmias in CKD, biomarkers of cardiac overload and injury were associated with most arrhythmias tested. Lower potassium and lower magnesium demonstrated a significant relationship with AF and VE, respectively. Our results suggest cardiac alterations as key conditions behind high arrhythmic burden in CKD, with somewhat limited contributions of electrolytes and anemia.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
