Abstract P020: High-sensitivity Cardiac Troponin T is an Independent Predictor for Coronary Artery Disease in Japanese Population: The Circulatory Risk in Communities Study

Abstract

Background: Coronary heart disease (CHD) has become No.1 cause of death in the world. Therefore, it is important to seek new predicting indicators to capture high risk individuals of CHD. Cardiac Troponin T in healthy individuals may be a candidate of predictor. Hypothesis: High-sensitivity cardiac Troponin T (hs-cTnT) is an independent predictor for incident CHD in general population. Methods: We conducted a nested case-control study in four Japanese communities of the Circulatory Risk in Communities Study (CIRCS). We investigated 120 cases (81 men and 39 women, aged 38-86 years) of first incident CHDs between 2001 and 2011, and 240 controls matched with age, sex, communities and the year of examination. Serum hs-cTnT levels were measured by electrochemiluminescence immunoassay. We used the serum storing at –80°C. The median (range of) period until the incidence of CHD was 2.0 years (4 days to 9.5 years) among cases. The incidence of CHD was ascertained by systematic active surveillance. Odds ratios (ORs) and 95% confidence intervals (CIs) for the risk of incident CHD were calculated with conditional logistic regression analyses. We calculated the ORs for each quartile of hs-cTnT against the lowest quartile as a reference. The adjustment variables included body mass index, systolic blood pressure, antihypertensive medication use, diabetes mellitus, serum total cholesterol, serum high-density lipoprotein cholesterol, and drinking status. Results: The distribution of hs-cTnT was from ≤0.003 ng/mL (measurement limit) to 0.155 ng/mL. The percentage of cases in each quartile of hs-cTnT was 24.7% (23/93) in the lowest quartile (≤0.004 ng/mL), 30.5% (29/95) in the second quartile (0.005 to 0.007 ng/mL), 38.4% (33/86) in the third quartile (0.008 to 0.011 ng/mL) and 40.7% (35/86) in the highest quartile (≥0.012 ng/mL). The ORs for incident CHD were 1.73 (95%CI: 0.83 to 3.58) for the second quartile, 2.63 (1.21 to 5.68) for the third quartile, and 2.90 (1.33 to 6.32) for the highest quartile against the lowest quartile. Each multivariable OR was 1.59 (0.74 to 3.45), 2.50 (1.08 to 5.77), and 2.61 (1.10 to 6.20), respectively. Conclusions: In conclusion, hs-cTnT was an independent predictor for CHD in Japanese general population.