Abstract
To investigate the incidence of recurrent Kawasaki disease, data of nationwide surveys of Kawasaki disease in Japan from January 2003 (18th survey) to December 2012 (22th survey) are analyzed. Our group previously reported the incidence rate of recurrent Kawasaki disease (Nakamura et al., 1994 and Hirata et al., 2001). In the current study, 104,751 patients with 498,388.9 person-years are observed to calculate the rate of recurrence. The incidence rate of recurrence is 4.14 per 1,000 person-years, with a high incidence within the 12 months from the first episode. The observed person-year categorized by some variables is calculated, such as sex, age at first episode, period of time after the initial episode, presence of cardiac sequelae in the acute (within 2 months) and late (after 2 months) stage, exposure to intravenous gamma globulin (IVGG) therapy, presence of additional IVGG administration, and exposure to steroid therapy. Using those data, incidence rate of recurrent Kawasaki disease and incidence rate ratio are calculated according to such variables, and potential risk factors for recurrence of Kawasaki disease are discussed.
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