Abstract
Radiofrequency ablation (RFA) has a high local control rate for lesions < 4 cm; however, it is limited in the treatment of larger tumors, in part due to tumor blood flow that dissipates local heat and limits ablation diameter. Reducing tumor blood flow prior to RFA may increase ablation diameter and improve treatment outcomes in patients with lesions > 4 cm. It has been previously shown that a systemic antiangiogenic agent can improve tumor ablation but the optimum timing between applying antiangiogenic therapy and ablation is unknown.
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