Abstract LB-20: Serum antioxidant levels and survival time in advanced non-small cell lung cancer patients.

Abstract

Abstract Background: Oxidative stress is involved with carcinogenesis of lung cancer and promotes tumor growth. Antioxidants play roles in inhibition of oxidative stress; consequently slow progression of tumor growth. This study aimed to show the correlation between median survival in advanced-stage non-small cell lung cancer (NSCLC) patients and antioxidant levels. Methods: Newly diagnosed advanced-stage NSCLC patient in Khonkaen University Hospital during June 2006 and June 2008 were enrolled. Participants who had history of taking dietary supplements were excluded. Tumor data and nutritional status were evaluated in all patients. Serum from each participant was taken since the date of diagnosis to determine non-enzymatic antioxidants, trace element antioxidants, and peroxidase levels. Each antioxidant level was categorized into quartiles to analyze the correlation with survival time. Both univariate analysis and COX regression model which included nutritional status were used in the analysis. Results: Thirty patients with mean age of 59.8 (range, 35-82) were enrolled. The majority of patients was male (76%), malnourished (90%), had a history of smoking (80%), and received chemotherapy for treatment of NSCLC (73%). Patients with the highest quartile of zinc had significantly longer survival time than with the lowest quartile (14.7 Vs 5.6 months) in both univariate and multivariate analysis (P = 0.01 and 0.007, respectively); while the significance of manganese was proven in only univariate model. Other antioxidants levels including retinol, α-tocopherol, β-carotene, lycopene, β-cryptoxanthin, selenium, copper, and peroxidase did not demonstrate relationship with survival time. Conclusion: The low level of some antioxidants, particularly zinc, produced a significantly poor prognosis in advanced-stage non-small cell lung cancer patients. Citation Format: Kosin Wirasorn, Pranithi Hongprabhas, Veeradej Pisprasert, Kulthida Klarod, Patcharee Boonsiri. Serum antioxidant levels and survival time in advanced non-small cell lung cancer patients. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research; 2013 Apr 6-10; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2013;73(8 Suppl):Abstract nr LB-20. doi:10.1158/1538-7445.AM2013-LB-20