Abstract
Abstract I-kappa-B-kinase (IKKε) is a serine/threonine protein kinase that belongs to the IKK kinase family. Recent studies have shown that IKKε functions as a breast and ovarian cancer oncogene. Here we demonstrate frequent overexpression of IKKε in pancreatic ductal adenocarcinoma (PDA). We immunohistochemically evaluated 78 PDA using the avidin-biotin-peroxidase method and the anti-IKKε, rabbit polyclonal antibody. Elevated IKKε reactivity (IHC score 4–9) was observed in 64.1 % (50/78) PDAs, but in 0% (0/113) of non neoplastic pancreatic ductal epithelium (NMP) (p < 0.001). Kaplan-Meier analysis of overall survival (OS) revealed that patients with high IKKε-IHC scores (4–9) had a significantly shorter survival than that of patients with low IKKε -IHC scores (0–3) (Log-rang test p = 0.023), independent of either tumor stage or grade. These data indicate that deregulation of IKKε is a common event in PDA and might play an important role in the pathogenesis of this deadly disease. In addition, IKKε could serve as a prognostic marker and potential therapeutic target for PDA intervention. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr LB-144. doi:10.1158/1538-7445.AM2011-LB-144
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