Abstract
Abstract LIN28, a developmental regulator originally identified as a heterochronic mutant in C. elegans, functions as an RNA binding protein that regulates protein expression through effects on mRNA translation and through control of processing of the let-7 family of tumor suppressor microRNAs. Lin28 has two paralogs, Lin28A and Lin28B, and studies have revealed a role for these factors in a wide array of biological phenotypes including organismal growth and metabolism, sexual maturation, and oncogenesis. LIN28/let-7 act antagonistically to regulate the balance of self-renewal and differentiation in embryonic stem cells, and LIN28 is one of the factors shown to reprogram somatic cells to pluripotency. In pediatric cancers, high level expression of LIN28 is a consistent marker of germ cell tumor, frequently observed in neuroblastoma and hepatoblastoma, and activated by chromosomal translocation in Wilms tumor. Thus, the stem cell factor LIN28 is commonly dysregulated in pediatric tumors and may represent a novel therapeutic target. Citation Format: George Q. Daley. The stem cell factor LIN28 in pediatric cancer. [abstract]. In: Proceedings of the AACR Special Conference on Chromatin and Epigenetics in Cancer; Jun 19-22, 2013; Atlanta, GA. Philadelphia (PA): AACR; Cancer Res 2013;73(13 Suppl):Abstract nr IA17.
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