Abstract
Abstract Developmentally important signal transduction pathways such as those controlled by the secreted Wnt and Hedgehog (Hh) ligands are frequently exploited in cancerous cells to promote unfettered growth. We describe functional and chemical genomics-based efforts to recover actionable mechanisms sustaining cancer-associated Wnt and Hh signaling. Our findings extend the portfolio of druggable enzymes with anti-cancer relevance and reveal novel prosurvival mechanisms in cancerous cells. Citation Format: Lawrence Lum. Deconvoluting the molecular circuitry of cancerous cells with high-throughput experimentation. [abstract]. In: Proceedings of the AACR Special Conference on Translation of the Cancer Genome; Feb 7-9, 2015; San Francisco, CA. Philadelphia (PA): AACR; Cancer Res 2015;75(22 Suppl 1):Abstract nr IA13.
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