Abstract
Abstract Current chemotherapy approaches to prostate cancer need to be improved because of limitations by lack of specificity and systemic toxicity although docetaxel-based chemotherapy has been shown to improve the quality of life in patients with the advanced disease. Nanotechnology has prompted new and improved materials for biomedical applications with particular emphasis in therapy and diagnostics. Especially, magnetic nanoparticles (Fe3O4) have potential applications in drug delivery, cancer diagnosis and therapy. We have shown that magnetic nanoparticles would modify the effect of chemotherapy in cancer cells. In this study, we analyzed the combined effects of docetaxel and magnetic nanoparticles on prostate cancer cell lines (LNCaP, DU145, and PC3) and their mechanisms. The combination of docetaxel and magnetic nanoparticles more effectively inhibited cancer cell growth and induced apoptosis. Only magnetic nanoparticles produced reactive oxygen species (ROS), however did not inhibit cancer cell growth significantly. Magnetic nanoparticles were also found to have the effect on the expression of ABC transporter genes, and have the possibility to inhibit the PI3K-Akt-mTOR pathway. These results suggest that magnetic nanoparticles may result in favorable development of current chemotherapy for the advanced disease and leading to new tumor ablation therapies. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 784. doi:1538-7445.AM2012-784
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