Abstract
Abstract Currently available applicators for delivery of accelerated partial breast irradiation using a high dose afterloader, have treatment catheters close to the center of the balloon in fixed positions, restricting one’s ability to modify the dose to critical organs. Recently we developed a novel, dual balloon brachytherapy applicator using which one could optimize radiation dose by shaping the resection cavity with an outer balloon and allowing an inner balloon to selectively position the treatment catheters away from the central axis of the balloon based on cavity size. The Double Balloon Breast Brachytherapy applicator offers a unique design with adjustable treatment catheters, allowing for both optimized dose delivery and conformal avoidance of critical structures. This applicator is a single entry (1 cm incision), multi-channel high dose rate afterloader (HDR) accessory device. The treatment catheters can be expanded to an optimal location greater than or equal to 50% of the outer balloon diameter(> 1 cm diameter) - thereby optimizing dose delivery to the patient. The Conformal Double Balloon Breast Brachytherapy Device has the ability to optimize either conformality or homogeneity by allowing expansion of an inner polyurethane balloon to selectively position multiple treatment catheters significantly away from the central axis of an expanded outer polyurethane balloon. A model study of the Double Balloon Breast Brachytherapy Device was performed with a wide range of volumes of the lumpectomy cavity. Each case is scanned in a CT scanner and the data transported to a treatment planning system. Dosimetric parameters such as dose delivered to treatment site, different organs such as skin, ribs, etc are evaluated and compared against existing breast brachytherapy applicator devices. Both ultrasound and CT images clearly indicate that the quality of the Double Balloon Device images are comparable to other commercial devices. All catheters are distinguishable and can be reconstructed for treatment planning, and the balloon volume can be clearly delineated. Planning Treatment Volume (PTV) based on balloon volume can be easily generated and optimized dosimetry performed. Initial patient studies also indicate that using the double balloon applicator optimized dosimetry can be obtained thereby reducing the dose to critical structures such as skin and rib while maintaining the dose to the target. Citation Format: Manny R. Subramanian, Mike Cutrer, Rohit Mehta. New device for radiation delivery in breast cancer patients - double balloon applicator for optimal dose distribution [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2017; 2017 Apr 1-5; Washington, DC. Philadelphia (PA): AACR; Cancer Res 2017;77(13 Suppl):Abstract nr 4762. doi:10.1158/1538-7445.AM2017-4762
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
