Abstract
Abstract Background: Protein kinase Ciota (PKCiota) have been reported to be an important effector of oncogenic K-ras. Furthermore, PKCiota is correlated with tumor angiogenesis. The role of PKCiota in gastric cancer remains unclear. The aim of this study is to clarify the role of PKCiota in human gastric cancer. Methods: Twenty-eight patients with gastric cancer who underwent gastrectomy were enrolled. The expression of PKCiota mRNA was determined in clinicopathological factors. Next, the patients were divided into two groups: the PKCiota high expression group (n = 14) and low expression group (n = 14). 5-year survival rate, ERK mRNA, which was the gene of downstream K-ras, and VEGF mRNA were compared between the two groups. The prognostic factors were investigated by multivariate analysis. Results: High expressions of PKCiota mRNA were observed in undifferentiation, deeper tumor invasion (MP≤), advanced stage (Stage III, IV) and peritoneal dissemination (+). The 5-year survival rate in the PKCiota high expression group were lower than that in the PKCiota low expression group. The multivariate analysis revealed that high expression of PKCiota mRNA was an independent prognostic factor. The expressions of ERK mRNA and VEGF mRNA in the PKCiota high expression group were higher than that in the PKCiota low expression group. Conclusion: Our results indicate that PKCiota was correlated with tumor progression and angiogenesis. PKCiota may be a new prognostic factor in gastric cancer. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 446. doi:1538-7445.AM2012-446
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