Abstract
Abstract Background: Claudins are tight junction proteins that are critical for the sealing of cellular sheets and controlling paracellular ion flux. Members of the claudin family have been demonstrated to play an important role in carcinogenesis and tumor progression. Penile squamous cell carcinoma (SCC) is a major health problem in Brazil, corresponding to 2,1% of all brazilian men tumors and 5-year survival rate drops dramatically in patients with lymph node metastasis. Objective: The aim of this study was to determine the protein expression pattern of claudins in penile SCC and correlate it with the clinicopathological features of penile cancer. Method: Tissue microarray (TMA) comprising 101 cases of penile SCC were immunohistochemically stained for claudin-1, -3, -4, -5 and -7, with which TMA core showing more than 10% of positive membranous staining cells. Results: Claudin-1, -3, -5 and -7 were downregulated in 55%, 68%, 62% and 88% of penile SCC samples, respectively. Claudin-4 was overexpressed in 58% of the tumor samples. Strong correlation was found between downregulation of claudin-1 and -3 (p< 0.001). Absence of claudin-1, -3 and -5 was associated with urethral infiltration (p=0.03 and p=0.02 and p=0.019, respectively). Loss of claudin -1 and -3 was also associated with perineural invasion (p=0.05 and p=0.02, respectively). Conclusion: Our data provides the first evidence that claudins expression was decreased in areas of invasion and infiltration and could be related to evolution and prognosis of these tumours. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 4231. doi:1538-7445.AM2012-4231
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