Abstract
Consumption of fish has been reported to decrease coronary mortality among subjects with known coronary heart disease (CHD), whereas such an effect is less documented in healthy subjects. Few studies have distinguished between intake of fatty fish (defined as a content of long-chained n-3 polyunsaturated fatty acid, greater than 1 g per 100 g of fish) and intake of lean fish. Objective To assess the hypothesis that consumption of fatty fish is negatively associated with the risk of acute coronary syndrome (ACS) in healthy men. Methods In the Danish cohort-study Diet, Cancer and Health 27,178 men between 50 and 64 years of age were enrolled. In a validated food frequency questionnaire, participants gave information on dietary intake of fatty fish. During a mean follow-up period of 7.6 years, we identified all cases from this cohort (n=854) with an incident ACS-diagnosis in the Danish National Patient Registry. Diagnoses were verified through medical record review. In Cox proportional hazard models, we adjusted for several well established risk factors for CHD. Results Conclusion The risk of ACS was 30% lower among men in the highest 4 quintiles of fatty fish consumption, compared with men in the lowest quintile, in this large Danish cohort study. There was no dose-response association.
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