Abstract
Objective: Carotid intima media thickness (CIMT) is well-known marker of cerebrovascular & CVD outcomes. Recent literature has discussed association of sleep duration with stroke &CVD, but still limited evidence exists regarding the true relationship of sleep duration with CIMT. The aim of this study is to determine association of short& long sleep duration with CIMT. Method: Baptist Health South Florida, a not for profit organization, conducted a randomized, non-blinded controlled trial in 2014.This study examined effect of web based interventions on reducing CVD risk in employees. The inclusion criteria were physician diagnosed T2DM and/or Metabolic Syndrome. We used cross sectional data for analysis. Per CDC.gov guidelines, we categorized self-reported sleep duration (hrs) as short (<7), reference (≥7-<9) and long sleep (≥9). CIMT was measured via carotid US screening device by Panasonic CardioHealth Station. Result: Study population (n=183; 74% female, 49% Hispanic) with mean age 51±10 years. Mean CIMT(mm) in females [0.879±0.15] and males [0.911±0.19] was not different (p>0.05). Atherosclerotic plaque was defined as any obvious focal luminal encroachment > 1.2 mm. In multivariate logistic regression model, per hour increase in sleep duration was associated with twice the odds of increase in CIMT >1.2mm [OR 2.15;95% CI (1.15-4.02)]. However, once we compared the reference sleep with short and long sleep duration categories, we determined, as compared to 7-9 hrs (ref) of sleep, the odds of CIMT >1.2 in those sleeping <7 hrs [OR 1.23; 95% CI (0.27-5.53)] and those sleeping ≥9 hrs [OR 2.91; 95% CI (0.33-25.42)] were not significant in adjusted model. Conclusion: Although we observed that per hour increase in sleep was related to increase in CIMT >1.2mm (risk of plaque), but we did not find any significant increased risk of plaque in either short or long sleep duration. Longitudinal studies with larger sample size are needed to clarify this association.
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