Abstract
Abstract Twist, a highly conserved basic helix-loop-helix transcriptional factor, is a major inducer of epithelial-mesenchymal transition (EMT) and involved in different phases of tumorigenicity. The elevated Twist expression in cancer cells has been shown to promote metastasis and induce chemoresistance. In this study, we have investigated the mechanism of action by which Twist depletion induces chemosensitivity of lung cancer cells to chemotherapeutic agent. We found that knock-down of Twist expression by siRNAs sensitized H1299 cells to cisplatin by inhibiting mTOR activity. Inhibition of mTOR pathway using mTOR or S6K siRNAs led to potentiate cell death in cisplatin resistant H1299 cells. Our results suggest that suppression of Twist expression sensitized NSCLC cells to cisplatin treatment by down-regulating mTOR pathway. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 103rd Annual Meeting of the American Association for Cancer Research; 2012 Mar 31-Apr 4; Chicago, IL. Philadelphia (PA): AACR; Cancer Res 2012;72(8 Suppl):Abstract nr 2020. doi:1538-7445.AM2012-2020
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