Abstract
Background: Hypogonadism is a common finding in type 2 diabetes mellitus (T2DM) and is quite prevalent in the male patients. Thirty-three to fifty seven percent of T2DM men have low serum testosterone levels. When symptoms of hypogonadism are also taken into account, prevalence falls to 15- 20 percent. Insulin resistance is a major determinator of many macrovascular complications in diabetes. Aim: This study was designed to see the relationship between hypogonadism and insulin resistance. Secondary aim was to look whether this relationship was independent of obesity, microvascular or macrovascular complications. Methods: This cross-sectional study comprises of 353 diabetic men. Hypogonadism was defined as per the guidelines laid by the endocrine society. Insulin resistance was measured by HOMA IR. Results: The study found a significant inverse correlation between hypogonadism and insulin resistance. On applying regression analysis, hypogonadism is associated with insulin resistance (odds ratio: 1.088, 95% CI = 1.037-1.141, p value = 0.001). Conclusion: Insulin resistance is strongly associated with hypogonadism independent of obesity and complication status of diabetes. This association provide a possible path for intervention.
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