Abstract
Abstract One of the most important problems in hormonal therapy for prostate cancer is the acquirement of hormone-resistant and/or androgen-independent phenotypes. These cells are high-grade and lead to the eventual death. To characterize the molecular features of high-grade prostate cancer, we performed a gene-expression profile analysis by cDNA microarray coupled with laser microbeam microdissection from 10 frozen high-grade prostate cancer tissues and found dozens of trans-activated genes. Among of them, we identified RAM as an overexpressed gene in high-grade prostate cancers. The function of this protein is unknown, but it has a domain structure relating to mRNA splicing. We demonstrated that RAM protein was localized in the nucleus. Knock-down of RAM expression by siRNAs were observed a significant decrease of cell numbers. In contrast, RAM overexpression promoted cell proliferation. These findings suggest that RAM could be involved in cell survival and/or proliferation of prostate cancer, and that it should be a potential molecular target for development of novel therapeutics. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 1682. doi:10.1158/1538-7445.AM2011-1682
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