Abstract 14928: Efficacy and Safety of Transradial Multi-vessel Coronary Artery Disease Intervention as Compared With Single Vessel Disease Intervention

Abstract

Backgroud: Transradial percutaneous coronary intervention (PCI) has evolved into a viable alternative to the traditional transfemoral approach. Clinical aspects related to transradial PCI on multi-vessel disease have been seldom investigated and reported. The aim of this study is to evaluate safety and efficacy of transradial intervention (TRI) for patients with multi-vessel disease as compared with single vessel disease. Method: A total of 1,690 consecutive patients underwent TRI were entered into multicenter Korean TRI Registry from Nov 2004 to Oct 2010. The patients were divided into two groups; Multi-vessel radial PCI group (n=424 pts) and Single vessel radial PCI group (n= 1266 pts). To adjust potential confounders, propensity score matched (PSM) analysis was performed using the logistic regression model (C-statics: 0.726). After PSM, total of 776 pts (388 pairs) were generated for this analysis. The primary study endpoint was 1-year major adverse cardiac event (MACE) defined as the composite of total death, myocardial infarction, target vessel revascularization (TVR) and stent thrombosis. Result: Baseline characteristics were well balanced between the two groups after PSM adjustment. At 1 year, the incidence of MACE was similar between the two groups (11.0% vs. 10.8 %, p=0.908, table). Although the multi-vessel radial PCI group had a longer procedure time (65.52±30.2 vs. 48.75±25.7 min, p<0.001) than the single-vessel PCI group, however, the incidence of contrast induced nephropathy was similar between the two groups (0.7% vs. 1.0%, p=0.725). Conclusion: In this study, although procedure time was longer in multi-vessel radial PCI group, transradial PCI was safe and effective in patients with multi-vessel disease. It might be favored over femoral artery as a primary access route for complex PCI.