Abstract 14615: Genome-Wide Association Study and Gene-Lifestyle Interaction of Dyslipidemia in Korean Population: Based on Gender Differences

Abstract

Introduction: Dyslipidemia is caused by the interaction between genetic variation and health-related lifestyle factors, and the incidences varies according to gender. The purpose of this study is to investigate the association between dyslipidemia-related single nucleotide polymorphisms(SNP) and health-related lifestyle factors in Korean cohorts. Hypothesis: We hypothesized that some SNPs affect the effects of lifestyle factors on the risk of dyslipidemia and analyzed gene-environment interactions to search interactive SNPs. Methods: Genotyping was conducted to determine genotypes of 72,298 people and investigate genotypes for 7,079,946 SNPs from Korean Genome and Epidemiology Study. We analyzed the effects of lifestyle factors such as diet, stress, physical activity, alcohol consumption, and smoking on dyslipidemia. After discovering SNPs with GWAS, the interaction between the SNPs and health-related lifestyle factors was confirmed. Results: Five SNPs were found to be associated with dyslipidemia in the entire cohort: rs117026536(LPL), rs651821(APOA5), rs9804646(APOA5), rs9926440(CETP), rs429358(APOE). In men, four SNPs were found to be associated with dyslipidemia, of which two were found only in men: rs662799(APOA5), rs56156922(CETP). Coffee intake and smoking experience had significant interaction with five SNPs in the entire cohort (p<0.05; p<0.05). SNPs of the LPL and the APOA5 showed significant interaction with drinking and exercising (p<0.05; p<0.05). Interestingly, there was a specific association between the risk of dyslipidemia and stress in men. rs662799(APOA5) showed significant interaction with stress (OR: 1.081, p=0.016). In addition, rs662799(APOA5) and rs56456922(CETP) had a significant interaction with the drinking period(p<0.05). Conclusion: These results revealed a substantial interaction between lifestyle factors and the SNPs of APOA5 and LPL genes in hyperlipidemia in Korean population. Moreover, a specific association was found between rs662799(APOA5) and stress in Korean men. Since there is a significant interaction between genetic variation and lifestyle factors according to gender, further studies considering these characteristics are needed.