Abstract 14294: Patients With Chronic Kidney Disease Have a Lower Odds of Ventricular Tachycardia Than General Population

Abstract

Introduction: Monomorphic ventricular tachycardia (VT) often results from scar formation secondary to chronic ischemia or myocardial infarction. Microvascular disease is a known risk factor for myocardial dysfunction as it can lead to focal scar formation and thus increase the risk for VT. Chronic kidney disease (CKD) is characterized by microvascular dysfunction on the basis of animal studies through metabolic, endocrine, and immune pathways and therefore was suspected to be a risk factor for developing VT. Methods: We conducted a retrospective cohort study utilizing the Healthcare Cost and Utilization Project National Inpatient Sample (HCUP-NIS) 2019 database to investigate hospitalizations for patients aged 18 years old or older with VT based on stage of CKD. Comorbidities were identified through their international classification of diseases, 10th revision (ICD-10 codes) recorded in the discharge record for each hospitalization. Records having cocaine or other stimulants were excluded. An alpha (p) value less than 0.05 was considered statistically significant. Results: A total of 456,925 patients were identified based on the inclusion and exclusion criteria above. The number of patients that had VT with and without CKD was 163,760 (3%) and 293,165 (1%), respectively. However, after an adjusted analysis was performed we discovered that the odds ratio of VT in patients with CKD was 0.735 (95% CI 0.720-0.751). Conclusions: In our retrospective cohort study, patients with CKD were found to have a lower risk of developing VT. This is suspected to be due to electrolyte derangements, such as hyperkalemia and hypermagnesemia, commonly seen in these patients and thus creating a cardioprotective electrolyte balance.