Abstract 14113: Age-Related Demographic Trends in Mortality Due to Ischemic Heart Disease in the United States From 1999 to 2019

Abstract

Introduction: United States Ischemic heart disease (IHD) mortality has decreased recently. mortality trends for demographic groups across different ages have not been well described. Hypothesis: Different age groups have different IHD mortality trends Methods: WWe performed a nationwide analysis using the CDC WONDER database to evaluate IHD mortality trends from 1999 to 2019. Crude mortality rates per 100,000 were evaluated by sex, race, ethnicity and ten-year age groups. We used Joinpoint linear regression to assess average annual percentage change (AAPC) in IHD-related mortality. Results: From 1999 to 2019, IHD mortality decreased from 189.8 to 110.0/100,000 (AAPC -2.9%, 95% CI -3.3 to -2.6%) nationally. Compared to the 65-74 year age group (AAPC -1.7%, 95% CI -1.9 to -1.4%), decline in IHD-related mortality was lower for 35-44 year (-0.4%, 95% CI -0.4 - 0.0%; p < 0.001), 45-54 year (-0.4%, 95% CI -0.5 to -0.3%; p < 0.001), and 55-64 year (-0.5%, 95% CI -0.8% to -0.2%; p < 0.001) age groups but similar for the 75-84 year group and higher for ≥85 year age group. Black populations had the highest mortality rates among men and women across all age groups except men ≥85 years old. All the studied groups had significant decreases in mortality between 2002 and 2010. From 2010 to 2019, all groups had significant decreases in mortality except for 35-44 year-old minority groups (black women AAPC -0.7%, 95% CI -2.3% to 1.0%; black men -0.6%, 95% CI -1.7% to 0.6%; Hispanic women 0.9, 95% CI -1.7% to 3.6%; Hispanic men 0.3%, 95% CI -0.9% to 1.5%) (Figure). Conclusions: U.S. populations <65 years old have had slower declines in IHD-related mortality than those ≥65 years, and black populations continue to have the highest IHD-related mortality across almost all age groups. Since 2010, black and Hispanic populations between 35 and 44 years old have not had significant decreases in IHD-related mortality. Greater focus on prevention and treatment of IHD in younger and minority populations is needed.