Abstract 13713: Short-Term Outcomes of Acute Mitral Regurgitation in Patients With Takotsubo Cardiomyopathy

Abstract

Introduction: Takotsubo cardiomyopathy (TC) is characterized by significant transient left ventricular dysfunction that is not due to obstructive coronary artery disease. Acute mitral regurgitation (MR) has been described in previous studies as a complication of TC, but short-term outcomes are not well studied. The aim of our study was to investigate the rates and outcomes of patients diagnosed with TC with acute MR in the Veteran Affairs (VA) system. Methods: We performed a retrospective study using chart review for patients diagnosed with TC between 2005 and 2018 in the VA national database. We included patients who met the Mayo Clinic diagnostic criteria for TC. We collected data for demographics, clinical course, and outcomes. Results: 287 patients (70.7% males) were included, Median age was 64 years, 18.8% were known to have coronary artery disease, 34.1% were diabetic and 60.3% had hypertension. 96% of patients had apical variant of TC. Moderate to severe MR was present in 8.7%; of those 48% were either new or significantly worsened MR when compared to previous echocardiograms prior to TC. MR was mostly diagnosed in patients with apical TC (91.7%). There was no significant difference in the rates of diagnosis of new MR in men compared to women (3.4% vs 6% p=0.34). There was also no significant difference in the in-hospital mortality rates between patients with new moderate-severe MR vs no-trivial MR (0% vs 8.7%, p = 0.61). At 30-day follow up there was no significant difference in mortality rates in patients with moderate-severe MR compared to no-trivial MR (9.1% vs 2.5%, p = 0.22). On follow up echo for patients who survived, all patients had resolution of the MR. Conclusions: In patients diagnosed with TC with new moderate-severe MR, there was no significant difference in mortality rates in the hospital or at 30-day follow up.