Abstract 12147: Heart Failure With Preserved and Reduced Ejection Fraction in Middle Eastern Arab and South Asian Patients Hospitalized in a Middle-Eastern Country (1991-2013)

Abstract

Objectives: The epidemiology of patients with heart failure (HF) remains largely unexplored in some ethnicities. The aim of the current study was to examine the clinical characteristics, treatment and in-hospital outcomes of Middle Eastern Arabs and South Asian patients hospitalized with HF in a Middle-Eastern Country and compare different subsets of patients according to the degree of left ventricular (LV) dysfunction using a large national registry. Methods: Retrospective analysis of patients hospitalized with HF in Qatar from January 1991 through June 2013 was made. Patients were divided into 3 groups according to LV ejection fraction (EF) on echocardiography; HF with preserved EF (HFpEF)= EF ≥50%, HF with reduced EF (HFrEF)= EF≤40%, and (HFpEF, borderline)= EF 41-49%. Patients risk profiles, management and in-hospital outcomes were compared in the 3 groups. Results: During study period 3114 patients were hospitalized with HF; 637(20.5%) with HFpEF, 415(13.3%) with (HFpEF, borderline) and 2062(66.2%) with HFrEF. Patients with HFpEF were the oldest in age, had the highest body mass index and the highest rates of associated atrial fibrillation and valvular heart disease. Patients with (HFpEF, borderline) had the highest rates of hypertension, diabetes mellitus, chronic kidney disease, dyslipidemia, old myocardial infarction and associated acute coronary syndromes whereas patients with HFrEF had the highest rates of smokers [Table]. There were no significant differences in the length of hospital stay among the 3 groups while the in-hospital mortality was significantly highest among patients with HFrEF. Conclusions: The current study explored for the first time HF in Middle Eastern Arabs and South Asian ethnicities according to the degree of LV function. HFrEF was the commonest class accounting for two thirds of hospitalizations with HF and was associated with higher in-hospital mortality. Further studies with long term follow-up data are warranted.