Abstract
Abstract Maxillary sinus squamous cell carcinoma (MSSCC) comprises 2-3% of all cancers of head and neck tumor and the annual incidence rate is 0.5-1.0 per 100,000 populations. After introduction of multimodality treatment comprising radiation therapy along with concomitant intra-arterial chemotherapy, rates of local control was improved. However the prognosis of advanced MSSCC is still worse. The 5-years survival rate of T4 tumors is 50% around. Local recurrence is the most common cause of treatment failure and death. Greater understanding of the molecular oncogenic pathways in MSSCC could help improve diagnosis, therapy, and prevention of the disease. MicroRNAs (miRNAs), non-coding RNA 21-25 nucleotides in length, regulate gene expression primarily at the posttranscriptional level. Growing evidence suggests that miRNAs are aberrantly expressed in many human cancers, and that they play significant roles in carcinogenesis and cancer progression. The expression signature of cancer related miRNAs could contribute as useful biomarkers for diagnosis and improvement of prognosis for MSSCC. No studies have been carried out for the purpose of identifying specific miRNA alterations in MSSCC. In this study, we performed the miRNA expression signature specific to MSSCC by evaluating 749 mature miRNAs expressions in 5 matched pairs of MSSCC tissues and normal maxillary sinus epithelium. A subset of 9 miRNAs was significantly down-regulated in our signature. Gain-of-function analysis revealed that miR-874 was significantly inhibited cell proliferation, suggesting miR-874 has a tumor suppressive function in MSSCC. We are continuing a search of target genes of miR-874 by using genome-wide gene expression analysis. The identification of tumor suppressive miRNAs and their target genes could provide new insights into potential mechanism of MSSCC carcinogenesis. Citation Format: {Authors}. {Abstract title} [abstract]. In: Proceedings of the 102nd Annual Meeting of the American Association for Cancer Research; 2011 Apr 2-6; Orlando, FL. Philadelphia (PA): AACR; Cancer Res 2011;71(8 Suppl):Abstract nr 121. doi:10.1158/1538-7445.AM2011-121
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