Abstract 12022: Cardiac Rehabilitation for Patients With Idiopathic Hypertrophic Cardiomyopathy

Abstract

Introduction: Cardiac rehabilitation (CR) is strongly recommended for patients with cardiovascular diseases, but a few studies on exercise training for hypertrophic cardiomyopathy (HCM) are reported. Objective: The aim of this study is to clarify whether supervised CR could improve the long-term prognosis of patients with HCM. Methods: Our multicenter cohort study included 590 idiopathic HCM patients recruited into supervised CR with anaerobic threshold (AT) level from 2004 to 2018, who were divided into two groups according to CR duration; CR until discharge (non-CR group) and continuous outpatient CR after discharge (CR group). Mortality and major adverse cardiovascular events (MACE) were compared between the groups by Kaplan-Meier and Cox hazard analyses. Results: Follow-up period after registration was 3.4±2.6 years. Patients in CR group were older and their ejection fraction (EF) was lower than those in non-CR group (68±12 versus 62±19 years; p<0.01 and 57±17 versus 63±15%; p<0.001, respectively). The HCM patients in CR group had worse survival and relatively higher risk of MACE than those in non-CR group by Kaplan-Meier analysis (log rank, p=0.01 and p=0.08, respectively). However, the risk of death and MACE was similar between two groups by Cox hazard analysis adjusted by age, gender, hypertension, dyslipidemia, diabetes, smoking, EF, beta blockers, angiotensin-converting-enzyme inhibitors, angiotensin receptor blockers and statins (p=0.16 and p=0.64, respectively). Conclusions: Exercise with AT level for HCM patients did not significantly increase mortality, but continuous CR for patients with HCM should be carefully considered.