Abstract
The absorption of glucose from the colon or rectum was evaluated in 6 adult patients. The amount and rate of expired C 14O 2 observed when C 14-glucose was given via the colon or rectum was similar to that observed after an intravenously administered C 14-glucose dose. However, the specific activity of glucose isolated from the blood at intervals up to 5 hours was extremely low when compared to that isolated from blood when the C 14-glucose dose was administered intravenously. The vast differences in blood glucose specific activity indicate the magnitude of absorption of glucose across the colon or rectal mucosa is insignificant and probably zero. The disappearance of C 14O 2 in the breath after antibiotic intestinal treatment indicated that glucose in the colon was oxidized to CO 2 or smaller carbon residues by intestinal bacteria which was then absorbed across the intestinal wall.
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