Abstract
The in-vivo absorption of phenol red, bromphenol blue and bromosulphonphthalein, as model drugs, was investigated after application to the rat gastric serosal surface using a cylindrical glass cell. Absorption ratios of model drugs were estimated to be greater than 37% in 4 h. Absorbed drugs appeared gradually in plasma and bile. Drug concentrations in the application site at 1 h were 16–660 times that in the non-application site in the stomach. Drug application to gastric serosal surface was effective with good absorption and efficient delivery to a local site in the stomach.
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