Abstract
The absorption, and the biliary and urinary excretion of radioactivity was studied in biliary fistulated rats and guinea-pigs given 35S-sporidesmin in an attempt to determine the factors responsible for the species difference in sensitivity to the mycotoxin sporidesmin. The absorption and excretion of radioactivity by both species was similar in both magnitude and rate. The enterohepatic circulation of sporidesmin or of its metabolites is reported. It is suggested that differences in the species' sensitivity to sporidesmin must lie in variations in sensitivity at the enzyme level, rather than in differences in absorption and excretion, leading to differing toxin concentrations within the susceptible tissues.
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