Abstract
A strong Th2-type immune response against Haemonchus contortus infection in genetically resistant sheep provide immunity. The objective of present study was to correlate mean faecal egg counts (FECs), absolute eosinophil counts and Th1/Th2 gene expression in resistant (R) and susceptible (S) Malpura sheep. In spite of no anthelmintic treatment in R line, on majority of the months, mean FECs remained significantly (P<0.05) lower compared to S line where anthelmintic treatment was given in September every year. R sheep possess a smaller number of blood eosinophils in the majority of months as compared with S sheep and a positive correlation has been observed between absolute eosinophil counts and mean FEC. In the condition, when FEC remain similar in both the lines (R and S), significantly (P<0.05) up-regulated expression of IL-5 was observed in R sheep compared with S sheep however when FEC is hugely enhanced; IL-2, IL-6, IL-12 and IL-13 gene expression was significantly (P<0.05) up-regulated in R sheep as compared to S sheep which is dependent on season and parasite load.
Published Version
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