Abstract
Background Many drugs used for cancer chemotherapy produce reactive oxygen species, thus leading to various complications including nephrotoxicity, cardiotoxicity, and ototoxicity. Objective We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss. Study Design and Methods This observational cohort study includes a pure-tone audiometry of the patients who underwent chemotherapeutic treatment. Medical history, presence of risk factors for hearing loss, toxic habits, and association with haplogroups have been determined. Results 40% of patients developed hearing loss after administration of cisplatin, which was bilateral and symmetrical and of high frequencies. The most frequent haplogroup was H with a slight overexpression of groups V and K and a low frequency of groups J and T. No association of the haplogroup types with the hearing loss has been found; however age was revealed as an important determining factor. Conclusions Ototoxicity caused by cisplatin is manifested as bilateral, symmetrical, and predominantly high frequency hearing loss. Although we did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss.
Highlights
IntroductionHuman mitochondrial DNA (mtDNA) haplogroups (subclades) are defined as genealogical groups of mitochondrial variants sharing a common maternal ancestor [1]
Human mitochondrial DNA haplogroups are defined as genealogical groups of mitochondrial variants sharing a common maternal ancestor [1]
We have provided a haplogroup analysis of a cohort of cancer patients treated with chemotherapy and compared factors associated with associated hearing loss
Summary
Human mitochondrial DNA (mtDNA) haplogroups (subclades) are defined as genealogical groups of mitochondrial variants sharing a common maternal ancestor [1]. Reported studies provide a correlation of mtDNA haplogroups with neurodegeneration and Alzheimer’s disease, cardiomyopathy, Parkinson’s disease, osteoarthritis, and diabetes [3,4,5,6,7]. All these disorders are accompanied by increased ROS, one of the major MDF markers. We did not find a strong correlation of haplogroups with ototoxicity, our results revealed the existence of a risk group of elderly patients over 60, which are more susceptible to hearing loss induced by cisplatin, than young adults, regardless of preexisting hearing loss
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