Absence of HMGIC-LHFP fusion in pulmonary chondroid hamartomas with aberrations involving chromosomal regions 12q13∼q15 and 13q12∼q14

Abstract

In a variety of benign solid human tumors the high mobility group protein gene HMGIC is affected by aberrations involving the chromosomal region 12q14∼q15. Beside the two predominant alterations t(3;12) (q27∼28;q14∼q15) and t(12;14)(q14∼q15;q23∼q24), the t(12;13)(q14∼q15;q12∼q14) is another aberration observed recurrently in these tumors. Very recently, an HMGIC-LHFP ( lipoma HMGIC fusion partner) fusion gene has been detected in a lipoma with a t(12;13). The results of the present study demonstrated the absence of the HMGIC-LHFP fusion in three pulmonary chondroid hamartomas (PCH) with complex aberrations involving chromosomal regions 12q13∼q15 and 13q12q∼q14 and one PCH with a simple t(12;13)(q14∼15;q13) by reverse transcription–polymerase chain reaction. Thus, intragenic rearrangements within the LHFP gene leading to its fusion to HMGIC are not a consistent finding in mesenchymal tumors with clonal aberrations of both chromosomal regions 12q13∼q15 and 13q12∼q14.