Abstract
Radiotherapy has a significant impact on the local tumor environment and its distant component. Abscopal effect is the bystander effect of radiotherapy observed at a site distant to that irradiated within the same subject. Abscopal effect even though described, is not a common clinical event. We report a documented observation of abscopal effect in a patient of Chronic Lymphocytic Leukemia during radiation therapy.
Highlights
The Abscopal effect is the effect of radiation therapy sometimes observed as response of tumour masses remote from the site of irradiation [1]
A 65 year old female patient, a known case of Chronic Lymphocytic Leukemia since two years, presented to us with a massive right axillary lymphadenopathy with severe pain and neurovascular pressure effects in the axilla. This patient at diagnosis, about two years back had presented with Right Axillay lymphadenopathy and was initially treated with chemotherapy COPP regimen for 3 cycles and switched over to Chlorambucil & prednisone
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Summary
The Abscopal effect is the effect of radiation therapy sometimes observed as response of tumour masses remote from the site of irradiation [1]. A 65 year old female patient, a known case of Chronic Lymphocytic Leukemia since two years, presented to us with a massive right axillary lymphadenopathy with severe pain and neurovascular pressure effects in the axilla This patient at diagnosis, about two years back had presented with Right Axillay lymphadenopathy (approx 6-8 cms, Multiple) and was initially treated with chemotherapy COPP (cyclophosphamide, vincristine, procarbazine, prednisone) regimen for 3 cycles and switched over to Chlorambucil & prednisone. The biggest node measured 14 × 12 × 10 cms with other axillary nodes ranging from 5 to 4 cms She had multiple (>1 cms) bilateral cervical lymphnodes (the largest 2 × 2 cms) at presentation were located in the right level II neck region away from the field of radiotherapy. One week after radiotherapy the lymphnodes in the neck which was unirradiated, and away from the field of radiotherapy, started regressing and by the end of two weeks of radiotherapy the lymphnodes in the neck had shown complete regression due to abscopal effect and the axillary node had a partial response with subjective improvement in symptoms and performance status (Figure 2). 6 months after radiation therapy the patient continues to have sustained palliation in the irradiatied and distant site
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