Abstract
Background Kawasaki Disease is a generalised systemic vasculitis involving blood vessels throughout the body, although the coronary arteries virtually always are involved. Previous evidence from echocardiographic, Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) studies of myocardial blood flow and flow reserve in KD patients revealed reduced hyperemic flows and flow reserve, suggestive of an impaired vasodilatory capacity. The aim of the study was to determine whether myocardial blood flow and flow reserve derived from perfusion Cardiac Magnetic Resonance Imaging (CMR), is impaired in children with a previous history of KD.
Highlights
Kawasaki Disease is a generalised systemic vasculitis involving blood vessels throughout the body, the coronary arteries virtually always are involved
Perfusion myocardial reserve was assessed by semi- quantitative methods (Mean Perfusion Reserve Index- MPRI)
Fourteen patients with known chronic KD underwent the Cardiac Magnetic Resonance Imaging (CMR) protocol. 5/14 patients presented with persisting epicardial lesions in Magnetic Resonance Angiography (MRA). 1/14 patient presented inducible perfusion defect
Summary
Kawasaki Disease is a generalised systemic vasculitis involving blood vessels throughout the body, the coronary arteries virtually always are involved. Previous evidence from echocardiographic, Single Photon Emission Computed Tomography (SPECT) and Positron Emission Tomography (PET) studies of myocardial blood flow and flow reserve in KD patients revealed reduced hyperemic flows and flow reserve, suggestive of an impaired vasodilatory capacity. The aim of the study was to determine whether myocardial blood flow and flow reserve derived from perfusion Cardiac Magnetic Resonance Imaging (CMR), is impaired in children with a previous history of KD
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