Abstract
Juvenile myoclonic epilepsy (JME) is the most frequent genetic generalized epilepsy syndrome. It typically occurs during adolescence with predominant myoclonic seizures, variably intermixed with generalized tonic-clonic and absences. Neurophysiological, neuropsychological and imaging studies in JME have shown focal abnormalities in the medial and dorsolateral prefrontal lobe. Our study's aim was to explore for additional evidence of focal cortical abnormalities in JME using advanced neuroimaging techniques.
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