Abstract

See related article, page 265. Atrial fibrillation (AF) is widely recognized as the most common cause of cardioembolic stroke in those aged >55 years. Less well appreciated are silent embolic infarcts and their impact on cognitive decline and vascular dementia. Hence, the prevention of both clinical and silent brain infarcts is the primary goal of effective AF treatment. Indeed, entire industries have been spawned to prevent stroke in AF. Warfarin is established as the benchmark stroke prevention treatment, although its risks and limitations are well known, not the least of which is underuse by …

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