Abstract
Deletions on the short arm of chromosome 1 (del 1p36) have been reported to be predictive of several malignant neoplasms. We tried to establish whether they have prognostic importance for testicular germ cell cancers in adults hoping to find an additional risk factor, which would help to optimize risk-adapted treatment concepts for early stage germ cell tumor patients. In a retrospective analysis of stage I germ cell tumor patients enrolled in surveillance programs double color FISH assays were used to detect aberrations at 1p36 in the primary tumors. For matched-pair analysis including known risk factors, FISH data of 16 relapsing and 16 non-relapsing patients (10 seminoma pairs and 6 non-seminomatous germ cell tumor pairs) were compared. This showed that aberrations at 1p36 were not predictive of recurrence in stage I germ cell cancer in adults.
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