Abstract

HIV Therapy is considered to be effective if it can reduce the viral load by 90% in less than 8 weeks and continue to suppress it to below 50 copies per mL of plasma in less than 6 months [1]. This response time to therapy as well as the time to suppress the viral load can be estimated towards the development of an interruptible control strategy for the chemotherapy of HIV. The time estimates are parameter dependent, and as such, will vary from one individual to the other. These time estimates therefore, will be useful and can be used to aid clinicians with therapy and measurement scheduling. The model used in this paper has a total of ten parameters, but in order to determine these time estimates, one only needs to know estimates for the death rate constants for the virus and actively infected CD4+ T cells, the combined drug efficacy, as well as the reproductive ratio.

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