Abstract
A variant of the human corticotropin-releasing factor receptor has been characterized. The variant has a 40-amino-acid deletion in the amino-terminal domain of the receptor and is the only form of this receptor detectable in the individual from which it was isolated. In contrast to the high affinity expressed by the normal human CRF receptor, the receptor variant fails to bind [ 125I]oCRF With high affinity in transfected COS-1 cells. High concentrations of human CRF are required to elevate intracellular cAMP levels in the cells transfected with the variant receptor; EC 50 values of 301 and 0.55 nM were obtained in cells expressing the receptor variant and normal CRF receptors, respectively.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: Biochemical and Biophysical Research Communications
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
