Abstract
A quantitative densitometric high-performance thin-layer chromatographic method for analysis of sertraline hydrochloride, estimated as sertraline, in pharmaceutical preparations has been established and validated. Sertraline was separated and identified on silica gel 60 F 254 HPTLC plateswith chloroform-ethyl acetate-triethylamine 5:3:0.2 ( v/v ) as mobile phase. The plates were developed to a distance of 7 cm. Densitometric quantification was performed at 279 nm by reflectance scanning. Well resolved bands were obtained for sertraline. The method was validated for precision, recovery, specificity, and ruggedness. The calibration plot for sertraline was linear with r = 0.9988. The method is selective and specific with potential application in pharmaceutical analysis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
