Abstract
Background TRPC-mediated Ca entry has been implicated in the control of smooth muscle proliferation and might represent a pivotal mechanism underlying in-stent restenosis. As we have observed significant expression of TRPC3 in human smooth muscle from coronary arteries as well as from aorta, we tested the efficiency of a recently discovered TRPC3-selective Ca entry blocker, Pyr3 (10 μM) to prevent vascular smooth muscle proliferation and stent implantation-induced hyperplasia of human aorta.
Highlights
TRPC-mediated Ca2+ entry has been implicated in the control of smooth muscle proliferation and might represent a pivotal mechanism underlying in-stent restenosis
The effect of Pyr3 on proliferation was measured by detection of BrDU incorporation and PCNA expression in human coronary smooth muscle and microvascular endothelium, which displays significantly smaller expression levels of TRPC as compared to smooth muscle
Inhibitory effects of Pyr3 on stent implantation-induced arterial injury were tested using a novel in vitro model of in-stent hyperplasia in human arteries based on organ-typical culture of human aortic constructs
Summary
Sarah König1, Sara Browne1, Heinrich Mächler2, Gerald Höfler3, C Oliver Kappe4, Toma N Glasnov4, Marlen Braune5, Eric Wittchow5, Klaus Groschner1* From 18th Scientific Symposium of the Austrian Pharmacological Society (APHAR). Joint meeting with the Croatian, Serbian and Slovenian Pharmacological Societies. Graz, Austria. 20-21 September 2012
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
