Abstract

In this multi-center, randomized controlled trial, authors assessed survival and functional outcomes in patients with severe traumatic brain injury whose intensive care unit (ICU) treatment was guided by continuous intracranial pressure (ICP) monitoring compared with those patients whose treatment was guided by clinical examination and frequent imaging via computed tomography (CT) scan alone. In patients with ICP, monitoring treatments were tailored to maintain an ICP at or below 20 mm Hg. Treatment modalities included hyper-osmolar therapy with either mannitol or hypertonic saline, aggressive sedation with phenobarbital, hyperventilation, or surgical evacuation of hemorrhage/mass.

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