Abstract
Three metal complexes [Cu(FMIMDIP)2 ] (1), [Ni(FMIMDIP)2 ] (2) and [Co(FMIMDIP)3 ] (3) where, FMIMDIP=(((furan-2-yl)methylimino)methyl)-4,6-diiodophenol, were synthesized and characterized by various spectroscopy. The analytical data revealed a square planar geometry for 1 and 2 and an octahedral geometry for 3. The kinetic and thermodynamic parameters of the thermal decomposition steps were calculated from the thermograms. The quantum chemical parameters have been calculated using HOMO-LUMO energies and reveal the stability of the complexes. The DNA interaction of 1-3 towards calf-thymus DNA was investigated by absorption titration, fluorescence spectroscopy and gel electrophoresis. All the complexes bind to DNA via intercalation mode with binding constant (Kb ) values of 4.17×103 M-1 to 5.9×104 M-1 and also effectively cleave pBR322 DNA by oxidative and photolytic techniques. The synergistic action of metal chelates with ascorbic acid induced the generation of free radicals. The antibacterial activity of 1-3 was tested against B. thuringiensis, S. pneumoniae, E. coli, and P. putida. Complex 3 has the best activity among all the complexes.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
