Abstract
Infection of chick embryo neuroretinal (NR) cells by Rous sarcoma virus (RSV) results in neoplastic transformation and induction of sustained cell proliferation. Both cell transformation and multiplication depend on genetic information(s) only present in sarcoma viruses. However, the observation that NR cells infected with T-class temperature sensitive mutants of RSV are induced to multiply at nonpermissive temperature, in the absence of transformation, also suggests that “growth stimulation” and “transformation” may represent distinct information expressed by sarcoma viruses in NR cells. Using induction of cell multiplication as a genetic marker, it has been possible to isolate a mutant of RSV, designated td PA-101, in which the mitogenic and transforming properties are permanently dissociated in NR cells. This mutant is defective in transforming NR cells and chick embryo fibroblasts and does not produce sarcomas in chicks. Therefore, td PA-101 represents a novel class of nonconditional mutants of RSV which differ from other transformation defective viruses in fully retaining the capacity to induce NR cell proliferation.
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