Abstract
(1) Background: Orthosiphon stamineus Benth. is a traditional medicine used in the treatment of diabetes and chronic renal failure in southern China, Malaysia, and Thailand. Diabetes is a chronic metabolic disease and the number of diabetic patients in the world is increasing. This review aimed to systematically review the effects of O. stamineus in the treatment of diabetes and its complications and the pharmacodynamic material basis. (2) Methods: This systematic review was conducted following Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), using the databases ScienceDirect, PubMed, and Web of Science. (3) Results: Thirty-one articles related to O. stamineus and diabetes were included. The mechanisms of O. stamineus in the treatment of diabetes and its complications mainly included inhibiting α-amylase and α-glucosidase activities, antioxidant and anti-inflammatory activities, regulating lipid metabolism, promoting insulin secretion, ameliorating insulin resistance, increasing glucose uptake, promoting glycolysis, inhibiting gluconeogenesis, promoting glucagon-likepeptide-1 (GLP-1) secretion and antiglycation activity. Phenolic acids, flavonoids and triterpenoids might be the main components for hypoglycemia effects in O. stamineus. (4) Conclusion: O. stamineus could be an antidiabetic agent to treat diabetes and its complications. However, it needs further study on a pharmacodynamic substance basis and the mechanisms of effective constituents.
Highlights
Orthosiphon stamineus Benth. (Lamiaceae) is a perennial herb [1,2]
153 records were removed for the following reasons: duplicate studies, reviews, book chapters, patents, meeting papers, and non-English language papers
The results showed that clerodens A–D had inhibitory activities with IC50 values of 18.9 ± 1.2, 14.7 ± 0.48, 12.4 ± 1.5, and 6.8 ± 0.92 μmol/L, respectively, a little higher than the positive control aminoguanidine [16]
Summary
Orthosiphon stamineus Benth. (Lamiaceae) is a perennial herb [1,2]. O. stamineus is widely distributed in the tropical and subtropical regions [3], including southeast Asian countries (Indonesia, Malaysia, Thailand, Vietnam, Myanmar, Philippines) [4,5], southernChina [6], India [7], Australia [5], etc. O. stamineus is widely distributed in the tropical and subtropical regions [3], including southeast Asian countries (Indonesia, Malaysia, Thailand, Vietnam, Myanmar, Philippines) [4,5], southern. In addition to Orthosiphon stamineus Benth., it has other scientific names, Clerodendranthus spicatus (Thunb) c. [8,9,10] It is usually called “Shencha” in Chinese. It is called Cat’s whiskers [11], Misai Kucing [12], Java tea [13], and kumis kucing [14] in some Southeast Asian countries.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
