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Abstract
In accordance with PRISMA, we conducted a broad search for potentially relevant articles pertaining to genes associated with RA. Selected studies included those (1) published in English, (2) involving human participants, and (3) referencing specific genetic markers in association with a measure of RA. For subgroup comparisons, we analyzed 14 studies assessing children and 23 assessing adults. We also compared 18 dopamine-related to 19 non-dopamine related studies. The main analysis produced a non-significant overall effect size; however, our most interesting finding was that results varied by age group. We explore this as well as difference by outcome type and the relation of the gene studied to dopamine. Our findings vary by age group. However, due to heterogeneity we recommend more studies to answer some questions about a broader range of neurotransmitters, to include younger age groups, and to clarify difference by outcome type. We discuss issues of relevance to researchers to guide future meta-analyses. Prospero: International prospective register of systematic reviews. Available from: https://www.crd.york.ac.uk/PROSPERO/view/CRD42018090220.
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