A systematic approach to determine optimal composition of gel used in radiation therapy

Abstract

The design of experiment was used to find the optimal composition of N-isopropyl acrylamide (NIPAM) gel. Optical computed tomography was used to scan the polymer gel dosimeter , which was irradiated from 0 to 20 Gy. The study was conducted following a statistical method using a two-level fractional factorial plan involving four variables (gelatin—5% and 6%, NIPAM—3% and 5%, Bis—2.5% and 3%, and THPC—5 and 10 mM). We produced three batches of gels of the same composition to replicate the experiments. Based on the statistical analysis, a regression model was built. The optimal gel composition for the dose range 0–15 Gy with linearity up to 1.000 is as follows: gelatin (5.67%), NIPAM (5%), Bis (2.56%), and THPC (10 mM). The dose response of the NIPAM polymer gel attains stability about 24 h after irradiation and remains stable up to 3 months.