Abstract
A-60 years old woman has been observed in our outpatient clinic for several years. She has been uncontrolled for her asthma despite multi-drug therapy; [Fluticazone (FP) 800 μg/day+Salmeterol(SM l00 μg+Montelukast 10 mg+Theophilline 200 mg/day], presenting asthma control test (ACT) score as 13. We added Ciclesonide (CIC) to her therapy and replaced FP and SM with BFC. As a result, her pulmonary function and ACT score improved. The counts of eosinophils in induced sputum decreased significantly. Furthermore, during an observation period of 9 months, she had neither had an emergency visit nor an asthma exacerbation. While some physicians previously reported efficacy of Inhaled corticosteroids (ICS) combination therapy of FP and Beclomethasone (BDP), there are no reports concerning the efficacy and tolerability of ICS combination therapy of Budesonide/Folmoterol combination (BFC) and Ciclesonide-hydrofluoroalkane (CIC-HFA). This is the first case report of a persistent asthma patient succesfully treated by the ICS combination therapy of BFC and CIC-HFA.
Highlights
It is commonly known that the inflammation in asthma involves both central and peripheral airways [1]
There are several types of Inhaled corticosteroids (ICS) such as Fluticazone (FP), Budesonide, Beclomethasone or Ciclesonide (CIC), which are commonly used for asthmatics [6]
We present a successfully treated case of persistent asthmatics by ICS combination therapy; added CIC on Budesonide/Folmoterol Combination (BFC)
Summary
It is commonly known that the inflammation in asthma involves both central and peripheral airways [1]. There are several types of Inhaled corticosteroids (ICS) such as Fluticazone (FP), Budesonide, Beclomethasone or Ciclesonide (CIC), which are commonly used for asthmatics [6]. It has been documented that CIC-HFA as well as BDP-HFA deposited at a higher rate in peripheral airways compared to FP because particles in CIC and BDP are smaller than those in FP.
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