Abstract
A Study on the Role of Cartridge Based Nucleic Acid Amplification Test (CBNAAT) for Diagnosing Pediatric Tuberculosis in a Tertiary Care Hospital in Eastern India
Highlights
India accounts for one-fifth of the global tuberculosis (TB) incidence, with TB remaining one of the leading causes of childhood mortality and morbidity
Cartridge Based Nucleic Acid Amplification Test (CBNAAT) detected 6 cases of rifampicin resistance among the 105 cases detected by CBNAAT (5.7%)
CBNAAT assay is a rapid test which identifies both the presence of Mycobacterium tuberculosis (MTB) and rifampicin resistance associated with mutation of rpoB gene in a single test
Summary
India accounts for one-fifth of the global tuberculosis (TB) incidence, with TB remaining one of the leading causes of childhood mortality and morbidity. Bacteriological confirmation of TB in children is challenging due to difficulty in obtaining quality specimens, in the absence of which diagnosis largely depends on clinical judgement. Isolation of mycobacteria by culture, while considered as gold standard for diagnosing TB, takes 4–8 weeks and often requires expensive and sophisticated laboratory facilities which cannot be afforded in most resource-limited settings [9]. Both antigen and antibody TB ELISA tests are poorly sensitive and specific and are not recommended for diagnosis of tuberculosis [10]. Its exact utility in high burden situation is still not clear [11]
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